Table of Contents Complete PDF. Part V: Mechanical Disruption Methods/ Grinding ... solids can be reduced to very fine particles by grinding, part of which is dependent upon the topology of the grinding surfaces. In its various forms grinding can be used on wet, dry, and frozen samples, however it is most efficient on solid samples. One key characteristic of grinding is that friction .
· Single particle compressive crush strength tests were carried out on product granules using a benchtop scale Instron testing machine. The maximum force applied to break the particle was measured. A minimum of 10 particles from each condition were tested and the average and standard deviation of the crush strength were determined. The carbon, hydrogen and nitrogen content of the .